The Effect of 30-minute Ischemia on the Levels of IL6, TNF α, NO, Glutathione and Lactic Acid in the Hepatic Tissue of Rats with Hepatic Steatosis

ConclusionRats with steatotic livers undergoing 30-minute ischemia and reperfusion show significant elevation of TNF α and LA and reduction in IL6, GSH and NO in liver tissue, with poor survival after surgery, compared to non-steatotic rats. These findings suggest that steatotic livers are more susceptible to ischemia-reperfusion injury than lean livers.
Source: Hellenic Journal of Surgery - Category: Surgery Source Type: research