Testosterone reduces vascular relaxation by altering cyclic adenosine monophosphate pathway and potassium channel activation in male Sprague Dawley rats fed a high-salt diet

Conclusion:
Inhibition of potassium channel or adenylyl cyclase activation appears to contribute to the mechanisms by which a high-salt diet increases vascular tone. These effects were counteracted by orchidectomy in male Sprague Dawley rats.

Source: Therapeutic Advances in Cardiovascular Disease - April 12, 2013 Category: Cardiology Authors: Oloyo, A. K., Sofola, O. A., Anigbogu, C. N., Nair, R. R., Vijayakumar, H. S., Fernandez, A. C. Tags: Original Research Source Type: research