Utility of animal gastrointestinal motility and transit models in functional gastrointestinal disorders

Publication date: Available online 26 July 2019Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Ahmad A-Saffar, Shota Takemi, HiwaK. Saeed, Ichiro Sakata, Takafumi SakaiAbstractAlteration in the gastrointestinal (GI) motility and transit comprises an important component of the functional gastrointestinal disorders (FGID). Available animal GI motility and transit models are to study symptoms (delayed gastric emptying, constipation, diarrhea) rather than biological markers to develop an effective treatment that target the underlying mechanism of altered GI motility in patients. Animal data generated from commonly used methods in human like scintigraphy, breath test and wireless motility capsule may directly translate to clinic. However, species differences in the control mechanism or pharmacological responses of GI motility may compromise the predictive and translational value of the preclinical data to human.In this review we aimto provide a summary on animal modelsused to mimic GI motility alteration in FGID, and the impact of the species differences in the physiological and pharmacological responses on the translation of animal GI motility and transit data to human.
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research