Epigenetic alterations are associated with tumor mutation burden in non-small cell lung cancer

ConclusionTo our knowledge, this is the first report for direct link between the methylome alterations and TMB in NSCLCs. High TMB NSCLCs had more DNAm aberrance and copy number variations (CNVs). In addition, the TMB distribution of Chinese NSCLCs population is lower than that of TCGA.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research