BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state

Conclusions: Hence, BDNF is a key regulator of aPKC synthesis and phosphorylation and an essential mediator of the maintenance of a centralized chronic pain state. These findings point to BDNF regulation of aPKC as a potential therapeutic target for the permanent reversal of a chronic pain state.

http://www.molecularpain.com/content/9/1/12

Source: Molecular Pain - March 20, 2013 Category: Molecular Biology Authors: Ohannes MelemedjianDipti TilluMarina AsieduEdward MandellJamie MoyVictoria BluteCaleb TaylorSourav GhoshTheodore Price Source Type: research