Toll-like receptor 9 interaction with CpG ODN - An in silico analysis approach

Conclusion:
In this study, we present two structural models for the human and mouse TLR9 ECD in a complex with CpG ODN. Some features predicted by this model are consistent with previously reported experimental data. This complex model may lead to a better understanding of the function of TLR9 and its interaction with CpG ODN and will improve our understanding of TLR9-ligand interaction in general.

Source: Theoretical Biology and Medical Modelling - March 14, 2013 Category: Biomedical Science Authors: Wei ZhouYan LiXichun PanYuan GaoBeiping LiZhengliang QiuLong LiangHong ZhouJunjie Yue Source Type: research