Antagonism between Antiviral Signaling and Glycolysis

Publication date: Available online 23 July 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Anoop Singh Chauhan, Li Zhuang, Boyi GanRIG-I-like receptor (RLR)-mediated interferon production is critical for antiviral responses. A recent study (Zhang et al., Cell, 2019) uncovered a reciprocal inhibition between RLR signaling and glycolysis: lactate produced by glycolysis inhibits RLR signaling by binding to RLR signaling component mitochondrial antiviral-signaling (MAVS), whereas RLR activation suppresses glycolysis through inhibiting glycolysis enzyme hexokinase.

Source: Trends in Endocrinology and Metabolism - July 24, 2019 Category: Endocrinology Source Type: research