RCT: Digoxin reduces 30-day All cause hospital admission in older patients with chronic systolic heart failure

Source: Am J Med Area: News Heart failure is a leading cause of hospital admission and readmission in older adults. The authors of this RCT investigated the effect of digoxin on 30 day all cause hospital admission in older patients with heart failure and reduced ejection fraction. Ambulatory patients with chronic heart failure (ejection fraction ?45%) (n=6,800) were randomly assigned to digoxin or placebo. Of these, 3405 were aged ?65 years (mean age, 72 years and 25% were women). The main outcome in the current analysis was 30-day all-cause hospital admission.   The authors reported the following results:   . In the first 30 days after randomisation, all-cause hospitalisation occurred in 5.4% (92/1693) and 8.1% (139/1712) of patients in the digoxin and placebo groups, respectively, (hazard ratio [HR] 0.66; 95% confidence interval [CI], 0.51-0.86; P = .002). . Digoxin also reduced both 30-day cardiovascular (3.5% vs. 6.5%; HR, 0.53; 95% CI, 0.38-0.72; P < .001) and heart ...
Source: NeLM - Cardiovascular Medicine - Category: Cardiology Source Type: news