Neuroleptic dysphoria: revisiting the concept 50 years later.

CONCLUSION: Neuroleptic dysphoria is a valid construct, which has significant implications for treatment and outcome. It is now clear that it relates to dopamine activities in the nigrostriatal complex. Recent research has also raised the issue of whether neuroleptic dysphoria is a variant of extrapyramidal symptoms. Meanwhile, the role of dopamine in both the genesis of neuroleptic dysphoria and addictive behaviour has raised the issue of both conditions being different facets of the schizophrenic disease process. The recent interface of addiction and psychiatry research may have opened a new science: the science of subjective tolerability disorders. PMID: 15877718 [PubMed - indexed for MEDLINE]
Source: Acta Psychiatrica Scandinavica Supplementum - Category: Psychiatry Tags: Acta Psychiatr Scand Suppl Source Type: research