Systematic review and meta-analysis of effect of statins on cardiovascular and renal outcomes in patients with chronic kidney disease

Source: European Heart Journal Area: News This systematic review and meta-analysis investigated the balance of risks and benefits of statin therapy in patients with chronic kidney disease (CKD) and the effect of kidney function on statin use.   A literature search was conducted for prospective RCTs assessing the effects of statins on cardiovascular outcomes in people with CKD published between 1970 and November 2011. Thirty-one trials that include at least one event were identified, providing data for 48,429 patients with CKD, including 6690 major cardiovascular events and 6653 deaths.   The following findings were reported:   . Statin therapy produced a 23% relative risk (RR) reduction for major cardiovascular events (RR 0.77, 95% CI 0.70 to 0.85, p<0.001).   . Statin therapy reduced the risk of coronary events by 22% (0.78; 0.69 to 0.88)   . Overall, there was no effect of statin therapy on risk of stroke (0.79; 0.56 to 1.12)   ...
Source: NeLM - Cardiovascular Medicine - Category: Cardiology Source Type: news