Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect

Publication date: Available online 19 July 2019Source: Journal of Pharmacological SciencesAuthor(s): Takehiro Kawashiri, Shiori Shimizu, Nao Shigematsu, Daisuke Kobayashi, Takao ShimazoeAbstractOxaliplatin induces severe peripheral neuropathy. The effect of donepezil, a drug used for treatment of Alzheimer’s disease, on oxaliplatin-induced peripheral neuropathy was investigated using both in vivo and in vitro models. Donepezil effectively attenuated oxaliplatin- and cisplatin-induced inhibition of neurite outgrowth in cultured PC12 cells. In a rat model, repeated oral administration of donepezil (5 times/week for 4 weeks) ameliorated oxaliplatin-induced mechanical allodynia (von Frey test) and sciatic nerve axonal degeneration. Moreover, donepezil did not inhibit the anti-tumor activity of oxaliplatin in any cultured cancer cell line. Therefore, donepezil may be useful for managing oxaliplatin-induced peripheral neuropathy.
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research