R-CHOP preceded by blood-brain barrier permeabilization with engineered tumor necrosis factor-{alpha} in primary CNS lymphoma

In conclusion, NGR-hTNF/R-CHOP was safe in these heavily pretreated patients. NGR-hTNF enhanced vascular permeability specifically in tumoral/peritumoral areas, which resulted in fast and sustained responses.

Source: Blood - July 17, 2019 Category: Hematology Authors: Ferreri, A. J. M., Calimeri, T., Conte, G. M., Cattaneo, D., Fallanca, F., Ponzoni, M., Scarano, E., Curnis, F., Nonis, A., Lopedote, P., Citterio, G., Politi, L. S., Foppoli, M., Girlanda, S., Sassone, M., Perrone, S., Cecchetti, C., Ciceri, F., Bordigno Tags: Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research