Prospective cohort analysis: Pre-hospital lactated ringer's solution treatment and survival in out-of-hospital cardiac arrest

Source: PLoS Medicine Area: News The findings of this Japanese prospective, non-randomised observational study suggest that in Japanese patients experiencing out-of-hospital cardiac arrest (OHCA), the pre-hospital use of lactate Ringer's (LR) solution was independently associated with a decreased likelihood of a good functional outcome 1 month after the event, but with an increased likelihood of return of spontaneous circulation (ROSC) before hospital arrival. Pre-hospital use of LR solution was not associated with 1-month survival. Data for the study were obtained from national database and included a total of 531,854 patients meeting the criteria for inclusion and of these around a fifth received LR solution. In Japan, the management of OHCA can include an intravenous infusion of lactated Ringer's solution. The authors stress that in view of various limitations, including study design, the findings need to be verified in further studies before recommendations about the pre-hospital use of LR solution in patients ...
Source: NeLM - News - Category: Drugs & Pharmacology Source Type: news