Review: Oncogenes in non-small-cell lung cancer: emerging connections and novel therapeutic dynamics

Source: Lancet Respiratory Medicine Area: News This review aims to provide an overview of the developments in the area of non-small cell lung cancer (NSCLC), focusing on the functional associations between key oncogenes involved in tumour formation. These mechanisms are crucial in NSCLC onset and progression and are emerging as clinically relevant diagnostic and therapeutically actionable targets. The following topics are discussed:   . Oncogene addiction: the EGFR paradigm . Molecular profiling as a guide to therapy . Molecular lesions in squamous-cell carcinomas . Tumour heterogeneity . Resistance and kinase switching . Clinical phenotypes identified by genetic lesions . Biology and applications of microRNA profiles . Therapeutic strategies for personalised therapy . Outlook
Source: NeLM - News - Category: Drugs & Pharmacology Source Type: news