Systematic review and meta-analysis: Selected pregnancy and delivery outcomes after exposure to antidepressant medication

Source: JAMA Psychiatry Area: News The authors of this paper note that data on the potential risks of antidepressant use during pregnancy are conflicting. They carried out a meta-analysis to assess whether pre-natal antidepressant exposure is associated with risk for selected adverse pregnancy or delivery outcomes.   Data for the analysis were sourced through a search of various databases, including Medline, Embase and the Cochrane Library from the date the database started to 30th June 2010. Literature searches were independently carried out by 2 professional librarians with expertise in the areas of psychiatry and psychopharmacology. Data were extracted based on the study design, antidepressant exposure, adjustment for confounders, and study quality. Studies were suitable for inclusion if they were in the English-language and reported outcomes associated with pharmacologic treatment during pregnancy. A total of 3074 abstracts were reviewed, 735 articles were retrieved and 23 studies were included in the ...
Source: NeLM - News - Category: Drugs & Pharmacology Source Type: news