Toll-Like Receptor 4 Knockout Protects Against Isoproterenol-Induced Cardiac Fibrosis: The Role of Autophagy

Conclusions:
Our results suggest that TLR4 KO-induced cardioprotection against ISO-induced cardiac fibrosis is associated with reduced autophagy induction. Cardiac fibroblast autophagy participates in its own activation. The moderate inhibition of autophagic activity may be a new strategy for treating cardiac fibrosis.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 8, 2014 Category: Cardiology Authors: Dong, R.-q., Wang, Z.-f., Zhao, C., Gu, H.-r., Hu, Z.-w., Xie, J., Wu, Y.-q. Tags: Experimental Studies Source Type: research