Rivotril (clonazepam) 0.5 and 2 mg tablets and 1mg/mL Concentrate for Solution for Injection or Infusion - Roche Products Limited - Revised SPC

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Section 4.3  Contraindications has been updated to include "Rivotril must not be used in patients in a coma, or in patients known to be abusing pharmaceuticals, drugs or alcohol."   Section 4.4 Special warnings and precautions for use has been updated to include the warning that the concomitant use of Rivotril with alcohol or/and CNS depressants should be avoided. Such concomitant use has the potential to increase the clinical effects of Rivotril possibly including severe sedation, clinically relevant respiratory and/or cardio-vascular depression. This section has also been updated with further information about the development of physical and psychic dependence with the use of benzodiazepines.   Section 4.6 Fertility, pregnancy and lactation has also been updated to include further information relating to the teratogenic nature of anti-convulsant drugs and other factors relating to teratogenicity, such as genetics or the condition itself. ...
Source: NeLM - SPC Changes - Category: Drugs & Pharmacology Source Type: news