Regioselective hydroamination of diphenylphosphorylallenes to synthesize β-aminophosphine oxides

Publication date: Available online 17 July 2019Source: Journal of Saudi Chemical SocietyAuthor(s): Xin-Yu Gong, Yang Chen, Li-Heng Ruan, Yu-Ke Liu, Jing SunAbstractThe regioselective hydroamination of diphenylphosphorylallenes has been developed using secondary amines as the amination reagents. This reaction protocol could be realized under ligand and transition metal-free conditions at room temperature and is tolerated to a diverse range of diphenylphosphorylallenes and amine substrates, affording a series of β-aminophosphine oxides in good yields after the reduction of the enamine intermediates.
Source: Journal of Saudi Chemical Society - Category: Chemistry Source Type: research