Sequence divergence in the Treponema denticola FhbB protein and its impact on factor H binding

In this study, we conduct a comparative assessment of the sequence, properties, structure, and ligand binding kinetics of the FhbB proteins of strains 33521 and 35405. The biological outcome of the interaction of these strains with FH could differ significantly as 33521 lacks dentilisin activity. The data presented here offer insight into our understanding of the interactions of T. denticola with the host and its potential to influence disease progression. © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd
Source: Oral Microbiology and Immunology - Category: Microbiology Authors: Tags: Original Article Source Type: research