Involvement of TRPA1 activation in acute pain induced by cadmium in mice

Conclusions:
Cd excites sensory neurons via activation of TRPA1 and causes acute pain, the mechanism of which may be similar to that of Zn. The present results indicate that TRPA1 is involved in the nociceptive or inflammatory effects of Cd.

Source: Molecular Pain - February 28, 2013 Category: Molecular Biology Authors: Saeko MiuraKenji TakahashiToshiaki ImagawaKunitoshi UchidaShigeru SaitoMakoto TominagaToshio Ohta Source Type: research