Network meta-analysis: Comparative effectiveness and safety of oral phosphodiesterase type 5 inhibitors for erectile dysfunction

Source: European urology Area: News Phosphodiesterase type 5 inhibitors (PDE5-Is) including sildenafil, tadalafil, and vardenafil are currently the first-line therapy for erectile dysfunction (ED). However there are few comparative data investigating the effects of different classes of oral PDE5-Is.   To address this gap in knowledge a systematic search was performed in PubMed, Cochrane Library, and Embase to identify randomised controlled trials (RCTs) that compared different PDE5-Is (sildenafil, tadalafil, vardenafil, udenafil, mirodenafil, and avanafil) or PDE5-Is with a placebo for ED. The authors used network meta-analysis, i.e. they compared multiple treatments using both direct comparisons of interventions within RCTs and indirect comparisons across trials based on a common comparator. The primary outcomes for this study were the Global Assessment Questionnaire question 1 (GAQ-1), and change from baseline to study end in the International Index of Erectile Function-Erectile Function domain score ...
Source: NeLM - News - Category: Drugs & Pharmacology Source Type: news