Cohort study: Ondansetron in pregnancy and risk of adverse foetal outcomes

Source: No information given Area: News The authors of this paper note that although ondansetron is often used to treat nausea and vomiting during pregnancy, its safety in pregnancy has not been studied in detail.   This Danish historic cohort study used data from registries in Denmark to investigate whether the use of ondansetron during pregnancy was associated with an increased risk of adverse foetal outcomes, (defined as spontaneous abortion, stillbirth, any major birth defect, preterm delivery, low birth weight, and small size for gestational age).   A historical cohort of 608,385 pregnancies was identified from the registries and from this data on women who were exposed to ondansetron in pregnancy and those who were not. The data covered the period from January 1, 2004, through March 31, 2011 and were included (1:4 ratio) in a propensity-score-matched analyses of spontaneous abortion (1849 exposed women vs. 7396 unexposed women), stillbirth (1915 vs. 7660), any major birth defect (1233 vs. ...
Source: NeLM - News - Category: Drugs & Pharmacology Source Type: news