Perioperative beta-blockade: might the baby go out with the bath water?
Perioperative beta-blockade: might the baby go out with the bath water?
Clin Med. 2014 Dec;14(6):604-7
Authors: Mistry R, Walker D
Abstract
Perioperative β-blocker therapy has been advocated to reduce cardiac mortality and morbidity in high-risk cardiac patients undergoing non-cardiac surgery. Core data that supported this intervention and informed international societal guidelines has recently been withdrawn. A subsequent meta-analysis of the remaining data reporting excess mortality has re-opened the debate about the utility of β-blocker therapy in the perioperative period. Criticism of remaining trial designs and new insights into the protective mechanisms of β-blocker therapy in critical illness raise important questions that should now be addressed by a further robust, high-quality randomised control trial.
PMID: 25468844 [PubMed - in process]
Source: Clinical Medicine - Category: Journals (General) Authors: Mistry R, Walker D Tags: Clin Med Source Type: research
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