Tumor-released autophagosomes induces CD4 + T cell-mediated immunosuppression via a TLR2 –IL-6 cascade

ConclusionsHSP90 α on the surface of TRAPs programs the immunosuppressive functions of CD4+ T cells to promote tumor growth and metastasis. TRAPs or their membrane-bound HSP90 α represent important therapeutic targets to reverse cancer-associated immunosuppression and improve immunotherapy.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research