Baseline T cell dysfunction by single cell network profiling in metastatic breast cancer patients

ConclusionsFunctional T cell analysis suggests that baseline T cell functionality is hampered in metastatic breast cancer patients, at least in part mediated by the PD-1 signaling pathway. These preliminary data support the rationale for investigating the possible beneficial effects of adding PD-1 blockade to improve responses to TGF β blockade and radiotherapy.Trial registrationNCT01401062.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research