Horizon Scanning: pregabalin capsules as effective as levetiracetam for refractory partial onset seizures

Source: BioSpace Area: News Pfizer has reported top-line results for a Phase 3 study that showed Lyrica® (pregabalin) Capsules were as effective as levetiracetam as an adjunctive therapy in adult epilepsy patients experiencing refractory partial onset seizures.   The study was a randomised, double-blind, parallel-group, multicenter, comparative, flexible-dose study to compare pregabalin (300, 450, 600 mg/day) to levetiracetam (1,000, 2,000, 3,000 mg/day) in reducing partial onset seizure frequency in subjects with epilepsy. The primary efficacy endpoint was the responder rate, defined as the proportion of subjects who had at least a 50 percent reduction in the 28 day seizure rate (all partial seizures) during the 12-week maintenance phase, as measured from the 6-week baseline.   The top-line results indicate that the study met its primary endpoint by demonstrating that a comparable proportion of patients on pregabalin achieved at least a 50 percent reduction in the 28-day seizure rate ...
Source: NeLM - News - Category: Drugs & Pharmacology Source Type: news