NICE unlicensed evidence summary: Metformin in women with polycystic ovary syndrome not planning pregnancy

Source: NICE Area: Evidence > Drug Specific Reviews These evidence summaries review the published data for selected unlicensed or off-label medicines that are considered to be of significance to the NHS, where there are no clinically appropriate licensed alternatives. They provide information for clinicians and patients to inform their decision-making and support the construction and updating of local formularies   The latest summary addresses the off-label use of metformin in women with polycystic ovary syndrome not planning pregnancy. Five small RCTs included in a Cochrane systematic review, and 4 RCTs published after the Cochrane review, provide the evidence for this summary.   Key points include the following:   . There is no good evidence that regimens containing metformin are statistically significantly different from co-cyprindiol in controlling hirsutism in women with PCOS.   . Two small studies found no statistically significant difference between metformin and ...
Source: NeLM - Drug Specific Reviews - Category: Drugs & Pharmacology Source Type: news