Inhaled loxapine (Adasuve®) for agitation associated with schizophrenia and bipolar disorder

Source: London New Drugs Group Area: Evidence > Drug Specific Reviews · Loxapine is a first-generation (typical) antipsychotic used for the symptomatic management of psychotic disorders. · Loxapine inhalation is delivered via the breath-actuated Staccato® device, through which drug is quickly vaporised to form a small particle aerosol for systemic delivery after inhalation. · In December 2012, the EU Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion recommending the granting of a marketing authorisation for inhaled loxapine (Adasuve®) for the rapid control of mild-to-moderate agitation in adult patients with schizophrenia or bipolar disorder. · Loxapine inhalation is delivered via the breath-actuated Staccato® device, through which drug is quickly vaporised to form a small particle aerosol for systemic delivery after inhalation. After the patient starts to inhale, the drug is rapidly heated to peak temperature in less than 0.5 seconds and vaporised in less than 1 second.  The drug ...
Source: NeLM - Mental Health - Category: Psychiatry Source Type: news