OT‐1 Mice Display Minimal Upper Genital Tract Pathology Following Primary Intravaginal Chlamydia muridarum Infection

In this study, we compared chlamydial clearance and UGT pathology in OT‐1 transgenic mice and the corresponding C57BL/6J wild type mice following primary intravaginal C. muridarum infection. All CD8+ T cells in the OT‐1 mice respond only to the Ova 257‐264 peptide and are incapable of responding to other antigenic epitopes including those of Chlamydia. OT‐1 mice displayed vaginal chlamydial clearance comparable to the wild type animals. However, both oviduct and uterine horn pathology were minimal in the OT‐1 mice compared to the high degree of pathology observed in the wild type animals. These results strongly suggest that Chlamydia‐specific, not bystander, CD8+ T cells mediate the UGT pathological sequelae following genital chlamydial infection. © 2013 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
Source: FEMS Immunology and Medical Microbiology - Category: Microbiology Authors: Tags: Short Communication Source Type: research