Taurine enhances skeletal muscle mitochondrial function in a rat model of resistance training

Publication date: Available online 5 July 2019Source: PharmaNutritionAuthor(s): Mohammad Mehdi Ommati, Omid Farshad, Akram Jamshidzadeh, Reza HeidariAbstractTaurine (β-amino sulfonic acid; TAU) is the most abundant amino acid in the human body. Recently, the positive effects of TAU on cellular mitochondria has been considered as an interesting mechanism for its beneficial effects. On the other hand, skeletal muscle disorders are debilitating complications, which could affect patients’ quality of life. Moreover, increasing muscle performance and stamina without violating standard rules are of particular interest in athletes. The current study was designed to evaluate the effect of resistance training (RT) with and without TAU supplementation on skeletal muscle function. Rats underwent RT training for eight weeks. Concurrently, animals received TAU (100, 500, and 1000 mg/kg/day, gavage). It was found that TAU treatment significantly decreased animals weight gain and enhanced the weight carrying capacity in RT rats. Mitochondrial indices, including dehydrogenases activity, ATP level, and membrane potential were significantly increased upon TAU treatment. These data indicate the positive effects of TAU on skeletal muscle function and provide insight into its potential mechanism of action. Therefore, TAU could be feasibly used to enhance muscle function and stamina. Moreover, TAU could be considered as a potential preventive/therapeutic agent against muscle disorders linked t...

Source: PharmaNutrition - July 7, 2019 Category: Nutrition Source Type: research