Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain

Conclusions:
In this study, we demonstrate novel evidence that genetic mutations in the GCH1 gene modulate pain-like hypersensitivity. Together, the present data suggest that BH4 is not important for basal heat and mechanical pain, but they support the hypothesis that BH4 plays a role in inflammation-induced hypersensitivity. Our studies suggest that the BH4 pathway could be a therapeutic target for the treatment of inflammatory pain conditions. Moreover, the hph-1 mice provide a valid model to study the consequence of congenital deficiency of GCH1 in painful conditions.

Source: Molecular Pain - February 19, 2013 Category: Molecular Biology Authors: Arafat NasserOle BjerrumAnne-Marie HeegaardAnette MøllerMajbritt LarsenLouise DalbøgeErik DupontTroels JensenLisbeth Møller Source Type: research