The enemy of my enemy: PTEN and PLCXD collude to fight endosomal PtdIns(4,5)P2

Loss of the phosphoinositide 5-phosphatase OCRL causes accumulation of PtdIns(4,5)P2 on membranes and, ultimately, Lowe syndrome. In this issue, Mondin et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201805155) discover that a surprising partnership between PTEN and the phospholipase PLCXD can compensate for OCRL to suppress endosomal PtdIns(4,5)P2 accumulation.

Source: Journal of Cell Biology - June 30, 2019 Category: Cytology Authors: Del Signore, S. J., Rodal, A. A. Tags: Spotlight Source Type: research