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Although more studies are needed to establish the specific role of estrogen in corneal pathophysiology, we agree with Natarajan and Ravindran  about the possible association between hormonal variations and corneal alterations, whether topographic or biomechanical.1 We have to clarify, however, that the treatment provided to the patient in our case report consisted of a tibolone therapy for endometriosis rather than for infertility, as st ated by the letter's authors. Tibolone is a selective estrogen receptor modulator that rapidly converts to substances with estrogenic effect, such as 3α- and 3β-hydroxy-tibolone.
Source: Journal of Cataract and Refractive Surgery - Category: Opthalmology Authors: Tags: Letter Source Type: research