Revisiting the medication possession ratio threshold for adherence in lipid management

Source: Current Medical Research and Opinion Area: Evidence > Medicines Management > References Objective: We sought to evaluate the relationship between different levels of medication possession ratio (MPR) attained and achievement of clinically meaningful reductions in lipid levels. Methods: This was a retrospective cohort study of 4691 new statin users from the US Dept of Veteran Affairs (VA).  Subjects were required to be eligible for VA medical and pharmacy services throughout the 1-year study period from index date and to have complete data for exposure, outcome and adjustment variables.  MPR was defined as number of days supplied with prescription medication divided by days of observation. Main Outcome Measures: Achieving 25% or greater reduction from baseline in lipid levels for three lipid outcomes: non-high-density lipoprotein (non-HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and total cholesterol (TC). Results: We observed a statistically significant trend of an increasing proportion of study subjects achieving a ...
Source: NeLM - Cardiovascular Medicine - Category: Cardiology Source Type: news