Noninvasive Detection of Bladder Cancer by Shallow-Depth Genome-Wide Bisulfite Sequencing of Urinary Cell-Free DNA for Methylation and Copy Number Profiling [Molecular Diagnostics and Genetics]

CONCLUSIONS:
Bladder cancer can be detected noninvasively in urinary cfDNA by methylomic and copy number analysis without previous knowledge or assumptions of specific aberrations. Such analysis could be used as a liquid biopsy to aid diagnosis and for potential longitudinal monitoring of tumor load. Further understanding of the differential size and fragmentation of cfDNA could improve the detection of bladder cancer.

Source: Clinical Chemistry - June 27, 2019 Category: Chemistry Authors: Cheng, T. H. T., Jiang, P., Teoh, J. Y. C., Heung, M. M. S., Tam, J. C. W., Sun, X., Lee, W.-S., Ni, M., Chan, R. C. K., Ng, C.-F., Chan, K. C. A., Chiu, R. W. K., Lo, Y. M. D. Tags: Molecular Diagnostics and Genetics Source Type: research