Optimization and Comparison of Information-Dependent Acquisition (IDA) to Sequential Window Acquisition of All Theoretical Fragment Ion Spectra (SWATH) for High-Resolution Mass Spectrometry in Clinical Toxicology [Drug Monitoring and Toxicology]

CONCLUSIONS:
This vSWATH method for clinical toxicology demonstrated equivalent analytical sensitivity and specificity for untargeted drug screening and identification in urine samples. vSWATH provided the additional benefit of collecting all tandem mass spectrometry spectra in a sample, which could be useful in discovering low-abundance compounds not discovered by IDA.

Source: Clinical Chemistry - June 27, 2019 Category: Chemistry Authors: Whitman, J. D., Lynch, K. L. Tags: Drug Monitoring and Toxicology Source Type: research