CADTH rapid review: Probiotics for antibiotic-associated diarrhoea, clostridium difficile infection and irritable bowel syndrome

Source: Canadian Agency for Drugs and Technologies in Health (CADTH) Area: News This Canadian review examines the efficacy and safety of probiotics in antibiotic-associated diarrhoea (AAD), clostridium difficile infection (CDI) and irritable bowel syndrome (IBS).   A total of one health technology assessment, five systematic reviews/meta-analyses, and 25 RCTs were included in this review. Some of the findings reported were as follows:   . There is a lack of assessment and systematic reporting of adverse events in probiotic trials.   . Evidence from two meta-analyses indicated probiotics administered concurrently with antibiotics may reduce the incidence of AAD, with the most robust data coming from trials that administered S. boulardii and strains of Lactobacillus alone or in combination with other genera versus placebo.   . Two other meta-analyses suggested probiotics as adjunct to antibiotics may reduce the incidence of CDI in the primary prevention setting, but have little or no benefit in treating ...
Source: NeLM - News - Category: Drugs & Pharmacology Source Type: news