Human chorionic gonadotrophin (hCG) for preventing miscarriage

Source: Cochrane Area: Evidence > Drug Specific Reviews Background Recurrent miscarriage (RM) is defined as the loss of three or more consecutive pregnancies. Further research is required to understand the causes of RM, which remain unknown for many couples. Human chorionic gonadotrophin (hCG) is vital for maintaining the corpus luteum, but may have additional roles during implantation which support its use as a therapeutic agent for RM.     Objectives To determine the efficacy of hCG in preventing further miscarriage in women with a history of unexplained RM.   Search methods We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 September 2012) and reference lists of retrieved studies.   Selection criteria Randomised controlled trials investigating the efficacy of hCG versus placebo or no treatment in preventing RM. Quasi-randomised trials are included. Cluster-randomised trials and trials with a cross-over design are excluded.   ...
Source: NeLM - Drug Specific Reviews - Category: Drugs & Pharmacology Source Type: news