New Aspects of the Physiology of the GH-IGF-1 Axis.

New Aspects of the Physiology of the GH-IGF-1 Axis. Endocr Dev. 2013;24:96-105 Authors: Vottero A, Guzzetti C, Loche S Abstract Growth hormone (GH) secretion from the pituitary is regulated by a complex network of CNS and peripheral inputs. Circulating GH binds to its receptor and initiates a cascade of signaling events which involve the JAK2-STAT pathway, the PI3K/Akt pathway and the RAS/MAPK pathway, leading to the transcription of several genes, including insulin-like growth factor 1 (IGF-1), IGFBP3, ALS, and others. Recent findings indicate that nutrition plays an important role in GH secretion and action. Furthermore, data are emerging which suggest that the RAS-MAPK pathway as well as epigenetic regulation of transcription may be important in determining both circulating and locally produced IGF-1. PMID: 23392098 [PubMed - in process]
Source: Endocrine Development - Category: Endocrinology Authors: Tags: Endocr Dev Source Type: research