RCT: Comparison of sodium bicarbonate with fruits and vegetables for treating metabolic acidosis in CKD stage 4 hypertensive kidney disease

Source: Clin J Am Soc Neprol Area: News This RCT was conducted to identify whether fruits and vegetables that were base-producing rather than acid-producing were as effective at treating metabolic acidosis in stage 4 CKD as oral sodium bicarbonate.   Individuals with stage 4 (eGFR, 15-29 ml/min per 1.73 m2) CKD due to hypertensive nephropathy, had a plasma total CO2 (PTCO2) level < 22 mM, and were receiving angiotensin-converting enzyme inhibition were randomly assigned to 1 year of daily oral sodium bicarbonate (NaHCO3) at 1.0 mEq/kg per day (n=35) or fruits and vegetables dosed to reduce dietary acid by half (n=36). The authors noted that plasma eGFR did not differ at baseline and 1 year between groups. The following results were reported:   . One-year PTCO2 was higher than baseline in the sodium bicarbonate group (21.2±1.3 versus 19.5±1.5 mM; P<0.01) and the fruits and vegetables group (19.9±1.7 versus 19.3±1.9 mM; P<0.01), consistent with improved metabolic acidosis. ...
Source: NeLM - News - Category: Drugs & Pharmacology Source Type: news