Adenovirus‐mediated Interferon‐γ Gene Therapy Induced Human Pancreatic Carcinoma Capan‐2 Cell Apoptosis In Vitro and In Vivo

In this study, we examined the potential therapeutic effects of an adenovirus encoding human interferon gamma (Ad‐IFNγ) on pancreatic carcinoma cells Capan‐2 in vitro and in vivo. The results indicated that Ad‐IFNγ could significantly inhibit tumor cell growth via inducing cell apoptosis. After infection, IFNγ expressed durably and stably in xenografts, predominantly in tumor tissue, while much less in blood and liver. Thus, adenovirus‐mediated intratumoral injection of human IFNγ gene could be an effective gene therapeutic system for the treatment of pancreatic carcinoma. Anat Rec, 00:000–000, 2013. © 2013 Wiley Periodicals, Inc.

Source: The Anatomical Record Part B: The New Anatomist - February 9, 2013 Category: Anatomy Authors: Fa‐Jun Xie, Peng Zhao, Yi‐Ping Zhang, Fei‐Ye Liu, Xi‐Lin Nie, Ying‐Hui Zhu, Xin‐Min Yu, Qiu‐Qing Zheng, Wei‐Min Mao, Hong‐Yang Lu, Hong Wei, WenLin Huang Tags: Full Length Article Source Type: research