The effect of sildenafil on the elasticity of erythrocytes in homozygous sickle cell disease

Conclusion: The result of this study shows that sildenafil caused an initial increase in erythrocyte membrane elasticity in both HbSS and HbAA subjects, and this later decreased with increasing concentration of the drug possibly due to the dual effect of cyclic adenosine monophosphate (cAMP).
Source: Indian Journal of Medical Sciences - Category: Journals (General) Authors: Source Type: research