Association of a genetic variant in AKT1 gene with features of the metabolic syndrome

Publication date: Available online 17 June 2019Source: Genes & DiseasesAuthor(s): Fateme Sadat Eshaghi, Hamideh Ghazizadeh, Sakine Kazami Nooreini, Ameneh Timar, Habibollah Esmaeily, Mehrane Mehramiz, Amir Avan, Majid Ghayour-MobarhanAbstractMetabolic syndrome (MetS) is a clustering of metabolic abnormalities that is associated with increased risk of developing cardiovascular disease and type 2 diabetes. There is growing body of data showing the associations of genetic variants of the genes involved in the PI3K/AKT/mTOR pathway with diabetes and obesity. We aimed to investigate the association between MetS and its components with the genetic polymorphism in AKT1, rs1130233 (T>C). Total of 618 participants, recruited from Mashhad stroke and heart atherosclerosis disorder cohort (MASHAD study). Patients with MetS were defined by using international diabetes federation (IDF) criteria (n=326) and those without MetS (n=261) were recruited. Anthropometric and biochemical parameters were measured in all subjects. Genetic analysis for the rs1130233 polymorphism was performed, using the ABI-StepOne instruments with SDS version-2.0 software. Individuals with MetS had a significantly higher levels of BMI, waist-circumference, total cholesterol, triglyceride, high sensitivity-c reactive protein (hs-CRP) and blood-pressure, and lower concentrations of high density lipoprotein (HDL-C), compared to non-MetS individuals (P<0.05). The association between the rs1130233 and MetS was not sig...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research