High-dose ascorbic acid supplementation may increase risk of kidney stones in men

Source: JAMA Internal Medicine Area: News In this Research letter published early online in JAMA Internal Medicine, the authors briefly describe their research into whether ascorbic acid supplements were associated with kidney stones in a population-based, prospective cohort of men.   The Cohort of Swedish Men (COSM) recruited 48,850 men aged 45 to 79 years in 1997. Detailed diet and lifestyle data, including on use of ascorbic acid, were collected at baseline using a self-administered questionnaire. For this analysis, researchers excluded those with incorrect national registration numbers, implausible energy intake, pre-baseline cancer diagnosis, missing supplement use data, and those diagnosed as having kidney stones prior to baseline. They also excluded users of supplements other than ascorbic acid due to the possibility of confounding. For comparison, they repeated the analysis for multivitamin (only) users. First incident cases of kidney stones were ascertained using registry data.   During 11 ...
Source: NeLM - News - Category: Drugs & Pharmacology Source Type: news