NICE unlicensed medicine evidence summary: Midodrine for postural hypotension in adults

Source: NICE Area: Evidence > Drug Specific Reviews These evidence summaries review the published data for selected unlicensed or off-label medicines that are considered to be of significance to the NHS, where there are no clinically appropriate licensed alternatives. The summaries provide information for clinicians and patients to inform their decision-making and support the construction and updating of local formularies.   The latest summary addresses the use of midodrine for the treatment of postural (orthostatic) hypotension. This medicine does not have a UK marketing authorisation for this or any other indication, and there are no other medicines licensed in the UK for the treatment of postural hypotension. Midodrine is however licensed in the US for the treatment of symptomatic postural hypotension, and it is also licensed for use in several EU countries, including Germany, France, Ireland, Italy and Spain.   Two double-blind randomised controlled trials (RCTs) found that midodrine at a dose of 10mg TDS for ...
Source: NeLM - Cardiovascular Medicine - Category: Cardiology Source Type: news