Metabolic stress in cancer cells induces immune escape through a PI3K-dependent blockade of IFN γ receptor signaling

ConclusionsThese data revealed a strong impact of metabolic stress on the presentation of tumor antigens by MHC class I and suggest that this type of tumor escape takes place at hypoxic areas even during times of active T cell immunity and IFNy release.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research