Importance of uncharged polar residues and proline in the proximal two-thirds (Pro107--Ser128) of the highly conserved region of mouse ileal Na+-dependent bile acid transporter, Slc10a2, in transport activity and cellular expression

Conclusions:
The functional importance of proline and uncharged polar residues in the highly conserved region of mouse Slc10a2 was determined. This information will contribute to the design of bile acid-conjugated prodrugs for efficient drug delivery or SLC10A2 inhibitors for hypercholesterolemia treatment.

Source: BMC Physiology - Latest articles - February 4, 2013 Category: Physiology Authors: Tohru SaekiKosuke SatoShiho ItoKeisuke IkedaRyuhei Kanamoto Source Type: research