Korean Red Ginseng increases defective pol gene in peripheral blood mononuclear cells of HIV-1-infected patients; inhibition of its detection during ginseng-based combination therapy

ConclusionThe proportion of Δpol depends on template size as well as KRG treatment. HAART decreases the detection of Δpol.Graphical abstractInternal deletion in the pol gene (Δpol) can be induced by taking Korean Red Ginseng (KRG) and the proportion of Δpol increases with a longer target size of PCR. In both 1.2-kb and 3.0-kb targeting PCR, the Δpol was significantly lower during ginseng based combination therapy (GCT; KRG plus HAART) and HAART than in the KRG treatment period. The reason for this might be the reduction of Δpol detection by limit dilution effect.
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research