Proteus mirabilis uroepithelial cell adhesin (UCA) fimbria plays a role in the colonization of the urinary tract

In this report we used a uropathogenic P. mirabilis wild‐type strain and an isogenic ucaA mutant unable to express UCA in order to study the pathogenic role of this fimbria in UTI. Ability of the mutant to adhere to desquamated uroepithelial cells and to infect mice using different experimental UTI models was significantly impaired. These results allow us to conclude that P. mirabilis UCA plays an important role in the colonization of the urinary tract. © 2013 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
Source: FEMS Immunology and Medical Microbiology - Category: Microbiology Authors: Tags: Short Communication Source Type: research