Hybrid hydrogels for biomedical applications

Publication date: Available online 4 June 2019Source: Current Opinion in Chemical EngineeringAuthor(s): Luisa L Palmese, Raj Kumar Thapa, Millicent O Sullivan, Kristi L KiickThe use of hydrogels in biomedical applications dates back multiple decades and the engineering potential of these materials continues to grow with discoveries in chemistry and biology. New approaches have led to increasing complex hydrogels that incorporate both synthetic and natural polymers and functional domains for tunable release kinetics, mediated cell response, and ultimately use in clinical and research applications in biomedical practice. This review focuses on recent advances in hybrid hydrogels that incorporate nano/microstructures, their synthesis, and applications in biomedical research. Examples discussed include the implementation of click reactions, photopatterning, and 3D printing for the facile production of these hybrid hydrogels, the use of biological molecules and motifs to promote a desired cellular outcome, and the tailoring of kinetic and transport behavior through to achieve desired biomedical outcomes. Recent progress in the field has established promising approaches for the development of biologically relevant hybrid hydrogel materials with potential applications in drug discovery, drug/gene delivery, and regenerative medicine.Graphical abstract

Source: Current Opinion in Chemical Engineering - June 5, 2019 Category: Chemistry Source Type: research